The ß<sub>2</sub>-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1ß administration to rats.

Griffin, Éadaoin W; Yssel, Justin D; O'Neill, Eoin; Ryan, Katie J; Boyle, Noreen; Harper, Peter; Harkin, Andrew; Connor, Thomas

The ß₂-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1ß administration to rats.

Griffin, Éadaoin W; Yssel, Justin D; O'Neill, Eoin; Ryan, Katie J; Boyle, Noreen; Harper, Peter; Harkin, Andrew; Connor, Thomas.

Afiliação

Griffin ÉW; a Neuroimmunology Research Group, Trinity College Institute of Neuroscience, Trinity College , Dublin , Ireland.
Yssel JD; b Department of Physiology, School of Medicine , Trinity College , Dublin , Ireland.
O'Neill E; b Department of Physiology, School of Medicine , Trinity College , Dublin , Ireland.
Ryan KJ; c Neuropsychopharmacology Research Group, Trinity College Institute of Neuroscience, Trinity College , Dublin , Ireland.
Boyle N; c Neuropsychopharmacology Research Group, Trinity College Institute of Neuroscience, Trinity College , Dublin , Ireland.
Harper P; d School of Pharmacy and Pharmaceutical Sciences , Trinity College , Dublin , Ireland.
Harkin A; a Neuroimmunology Research Group, Trinity College Institute of Neuroscience, Trinity College , Dublin , Ireland.
Connor T; b Department of Physiology, School of Medicine , Trinity College , Dublin , Ireland.

Immunopharmacol Immunotoxicol ; 40(2): 99-106, 2018 Apr.

Article em En | MEDLINE | ID: mdl-29303018

Assuntos

Agonistas de Receptores Adrenérgicos beta 2/farmacologia; Lesões Encefálicas; Clembuterol/farmacologia; Interleucina-1beta/toxicidade; Infiltração de Neutrófilos/efeitos dos fármacos; Neutrófilos/metabolismo; Animais; Lesões Encefálicas/induzido quimicamente; Lesões Encefálicas/metabolismo; Lesões Encefálicas/patologia; Lesões Encefálicas/prevenção & controle; Inflamação/induzido quimicamente; Inflamação/metabolismo; Inflamação/patologia; Inflamação/prevenção & controle; Masculino; Neutrófilos/patologia; Ratos; Ratos Wistar

Palavras-chave

CINC-1; IL-1ß; apoptosis; clenbuterol; neutrophil; rat; striatum; ß2-Adrenoceptor

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Clembuterol / Infiltração de Neutrófilos / Interleucina-1beta / Agonistas de Receptores Adrenérgicos beta 2 / Neutrófilos Limite: Animals Idioma: En Revista: Immunopharmacol Immunotoxicol Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google