Genetic basis for relapse rate in multiple sclerosis: Association with LRP2 genetic variation.
Mult Scler
; 24(13): 1773-1775, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-29303040
ABSTRACT
BACKGROUND:
In contrast to successes for multiple sclerosis (MS) susceptibility, the genetic basis for clinical heterogeneity remains largely unresolved.OBJECTIVES:
We investigate the first reported genetic association with relapse rate.METHODS:
We genotyped variant rs12988804 in LRP2 in a homogeneous study population of 527 Belgian MS patients with 970 documented relapses.RESULTS:
The rs12988804*T allele is associated with a 1.16-fold increased hazard rate for a relapse occurring ( P = 0.0078) and a higher baseline relapse rate prior to immunomodulatory treatment ( P = 0.044).CONCLUSION:
Variant rs12988804 in LRP2, the first example of a genome-wide significant association with relapse rate in MS, is replicated in an independent study.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Proteína-2 Relacionada a Receptor de Lipoproteína de Baixa Densidade
/
Esclerose Múltipla
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Mult Scler
Ano de publicação:
2018
Tipo de documento:
Article