Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death.

Zdralevic, Masa; Vucetic, Milica; Daher, Boutaina; Marchiq, Ibtissam; Parks, Scott K; Pouysségur, Jacques

Zdralevic, Masa; Vucetic, Milica; Daher, Boutaina; Marchiq, Ibtissam; Parks, Scott K; Pouysségur, Jacques.

Afiliação

Zdralevic M; Université Côte d'Azur, Institute for Research on Cancer and Aging (IRCAN), CNRS, INSERM, Centre A. Lacassagne, 33 avenue de Valombrose, Nice, France.
Vucetic M; Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco.
Daher B; Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco.
Marchiq I; Université Côte d'Azur, Institute for Research on Cancer and Aging (IRCAN), CNRS, INSERM, Centre A. Lacassagne, 33 avenue de Valombrose, Nice, France.
Parks SK; Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco.
Pouysségur J; Université Côte d'Azur, Institute for Research on Cancer and Aging (IRCAN), CNRS, INSERM, Centre A. Lacassagne, 33 avenue de Valombrose, Nice, France; Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco. Electronic address: pouysseg@unice.fr.

Adv Biol Regul ; 68: 55-63, 2018 05.

Article em En | MEDLINE | ID: mdl-29306548

Assuntos

Morte Celular/fisiologia; Animais; Morte Celular/genética; Linhagem Celular Tumoral; Humanos; Lactato Desidrogenases/metabolismo; Ácido Láctico/metabolismo; Estresse Oxidativo/fisiologia

Palavras-chave

Cancer; Cystine transporter; GPI; Glycolysis; LDH isoforms; Lipid peroxidation; MCT; MonoCarboxylate transporters; OXPHOS; Pentose phosphate pathway; ROS; Warburg effect; xCT

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Morte Celular Limite: Animals / Humans Idioma: En Revista: Adv Biol Regul Ano de publicação: 2018 Tipo de documento: Article

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