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Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor.
Saleh, Noureldin; Hucke, Oliver; Kramer, Gert; Schmidt, Esther; Montel, Florian; Lipinski, Radoslaw; Ferger, Boris; Clark, Timothy; Hildebrand, Peter W; Tautermann, Christofer S.
Afiliação
  • Saleh N; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Institute of Medical Physics and Biophysics, Charitéplatz 1, 10117, Berlin, Germany.
  • Hucke O; Department for Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co KG, Birkendorfer Straße 65, 88397, Biberach an der Riss, Germany.
  • Kramer G; Department for CNS research, Boehringer Ingelheim Pharma GmbH & Co KG, Birkendorfer Straße 65, 88397, Biberach an der Riss, Germany.
  • Schmidt E; Department for Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co KG, Birkendorfer Straße 65, 88397, Biberach an der Riss, Germany.
  • Montel F; Department for Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co KG, Birkendorfer Straße 65, 88397, Biberach an der Riss, Germany.
  • Lipinski R; Department for Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co KG, Birkendorfer Straße 65, 88397, Biberach an der Riss, Germany.
  • Ferger B; Department for CNS research, Boehringer Ingelheim Pharma GmbH & Co KG, Birkendorfer Straße 65, 88397, Biberach an der Riss, Germany.
  • Clark T; Computer-Chemie-Centrum, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nägelsbachstraße 25, 91052, Erlangen, Germany.
  • Hildebrand PW; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Institute of Medical Physics and Biophysics, Charitéplatz 1, 10117, Berlin, Germany.
  • Tautermann CS; Universität Leipzig, Institute of Medical Physics and Biophysics, Härtelstraße 16-18, 04107, Leipzig, Germany.
Angew Chem Int Ed Engl ; 57(10): 2580-2585, 2018 03 01.
Article em En | MEDLINE | ID: mdl-29314474
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor CB1 de Canabinoide / Indóis Tipo de estudo: Guideline / Prognostic_studies Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor CB1 de Canabinoide / Indóis Tipo de estudo: Guideline / Prognostic_studies Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2018 Tipo de documento: Article