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Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold.
Lu, Biao; Huang, Song; Cao, Jingsong; Hu, Qiyue; Shen, Ru; Wan, Hong; Wang, Dan; Yuan, Jijun; Zhang, Lei; Zhang, Jiayin; Zhang, Minsheng; Tao, Weikang; Zhang, Lianshan.
Afiliação
  • Lu B; Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Rd, Minhang Hi-tech Zone, Shanghai 200245, China. Electronic address: lub@shhrp.com.
  • Huang S; Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Rd, Minhang Hi-tech Zone, Shanghai 200245, China.
  • Cao J; Eternity Bioscience Inc., 6 Cedarbrook Drive, Cranbury, NJ 08512, USA.
  • Hu Q; Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Rd, Minhang Hi-tech Zone, Shanghai 200245, China.
  • Shen R; Eternity Bioscience Inc., 6 Cedarbrook Drive, Cranbury, NJ 08512, USA.
  • Wan H; Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Rd, Minhang Hi-tech Zone, Shanghai 200245, China.
  • Wang D; Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Rd, Minhang Hi-tech Zone, Shanghai 200245, China.
  • Yuan J; Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Rd, Minhang Hi-tech Zone, Shanghai 200245, China.
  • Zhang L; Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Rd, Minhang Hi-tech Zone, Shanghai 200245, China.
  • Zhang J; Eternity Bioscience Inc., 6 Cedarbrook Drive, Cranbury, NJ 08512, USA.
  • Zhang M; Eternity Bioscience Inc., 6 Cedarbrook Drive, Cranbury, NJ 08512, USA.
  • Tao W; Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Rd, Minhang Hi-tech Zone, Shanghai 200245, China.
  • Zhang L; Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Rd, Minhang Hi-tech Zone, Shanghai 200245, China.
Bioorg Med Chem ; 26(3): 581-589, 2018 02 01.
Article em En | MEDLINE | ID: mdl-29317148
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofuranos / Quinases de Proteína Quinase Ativadas por Mitógeno / Inibidores de Proteínas Quinases Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofuranos / Quinases de Proteína Quinase Ativadas por Mitógeno / Inibidores de Proteínas Quinases Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2018 Tipo de documento: Article