Comparison of modified two-point dixon and chemical shift encoded MRI water-fat separation methods for fetal fat quantification.
J Magn Reson Imaging
; 48(1): 274-282, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29319918
ABSTRACT
BACKGROUND:
Fetal fat is indicative of the energy balance within the fetus, which may be disrupted in pregnancy complications such as fetal growth restriction, macrosomia, and gestational diabetes. Water-fat separated MRI is a technique sensitive to tissue lipid content, measured as fat fraction (FF), and can be used to accurately measure fat volumes. Modified two-point Dixon and chemical shift encoded MRI (CSE-MRI) are water-fat separated MRI techniques that could be applied to imaging of fetal fat. Modified two-point Dixon has biases present that are corrected in CSE-MRI which may contribute to differences in the fat measurements.PURPOSE:
To compare the measurement of fetal fat volume and FF by modified two-point Dixon and CSE-MRI. STUDY TYPE Cross-sectional study for comparison of two MRI pulse sequences. POPULATION Twenty-one pregnant women with singleton pregnancies. FIELD STRENGTH/SEQUENCE 1.5T, modified two-point Dixon and CSE-MRI. ASSESSMENT Manual segmentation of total fetal fat volume and mean FF from modified 2-point Dixon and CSE-MRI FF images. STATISTICAL TESTS Reliability was assessed by calculating the intraclass correlation coefficient (ICC). Agreement was assessed using a one-sample t-test on the fat measurements difference values (modified two-point Dixon - CSE-MRI). The difference scores were tested against a value of 0, which would indicate that the measurements were identical.RESULTS:
The fat volume and FF measured by modified two-point Dixon and CSE-MRI had excellent reliability, demonstrated by ICCs of 0.93 (P < 0.001) and 0.90 (P < 0.001), respectively. They were not in agreement, with CSE-MRI giving mean fat volumes 180 mL greater and mean FF 3.0% smaller than modified two-point Dixon. DATACONCLUSION:
The reliability between modified two-point Dixon and CSE-MRI indicates that either technique can be used to compare fetal fat measurements in different participants, but they are not in agreement possibly due to uncorrected biases in modified two-point Dixon. LEVEL OF EVIDENCE 4 Technical Efficacy Stage 1 J. Magn. Reson. Imaging 2018.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Natal
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Imageamento por Ressonância Magnética
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Tecido Adiposo
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Feto
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Magn Reson Imaging
Ano de publicação:
2018
Tipo de documento:
Article