Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modify Microglial Response and Improve Clinical Outcomes in Experimental Spinal Cord Injury.

Ruppert, Katherine A; Nguyen, Tin T; Prabhakara, Karthik S; Toledano Furman, Naama E; Srivastava, Amit K; Harting, Matthew T; Cox, Charles S; Olson, Scott D

Ruppert, Katherine A; Nguyen, Tin T; Prabhakara, Karthik S; Toledano Furman, Naama E; Srivastava, Amit K; Harting, Matthew T; Cox, Charles S; Olson, Scott D.

Afiliação

Ruppert KA; Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Nguyen TT; Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Prabhakara KS; Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Toledano Furman NE; Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Srivastava AK; Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Harting MT; Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Cox CS; Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Olson SD; Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA. scott.d.olson@uth.tmc.edu.

Sci Rep ; 8(1): 480, 2018 01 11.

Article em En | MEDLINE | ID: mdl-29323194

Assuntos

Vesículas Extracelulares/transplante; Microglia/metabolismo; Traumatismos da Medula Espinal/terapia; Animais; Astrócitos/citologia; Astrócitos/metabolismo; Modelos Animais de Doenças; Vesículas Extracelulares/metabolismo; Humanos; Inflamação; Locomoção/fisiologia; Masculino; Células-Tronco Mesenquimais/citologia; Células-Tronco Mesenquimais/metabolismo; Microglia/citologia; Neutrófilos/citologia; Neutrófilos/metabolismo; Ratos; Ratos Sprague-Dawley; Receptores de IgG/metabolismo; Recuperação de Função Fisiológica; Baço/citologia; Baço/imunologia; Resultado do Tratamento

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Microglia / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article

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