Treatment of mantle cell lymphoma in older adults.
J Geriatr Oncol
; 9(4): 308-314, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29325898
ABSTRACT
Mantle cell lymphoma (MCL) predominantly affects older adults, with a median age at diagnosis of 70years. A frequently aggressive yet incurable lymphoma, the goal of therapy for MCL is to turn a potentially life-threatening illness into a chronic disease with prolonged periods of remission. Large randomized trial data supports the standard treatment in younger patients of cytarabine-based induction followed by autologous stem cell transplant. Most patients will not be eligible for this intensive approach based on older age, comorbidities, and functional status, making the geriatric assessment an essential step in choosing the appropriate strategy. For these older patients, an increasing number of chemotherapy and non-chemotherapy based therapies are available that allow oncologists to better tailor treatment to the fitness of the patient. We will review treatment options for older patients with MCL in the first line and relapsed/refractory settings, highlighting the available evidence for providing longer progression-free intervals while also minimizing the adverse effects of unduly aggressive treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
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Avaliação Geriátrica
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Linfoma de Célula do Manto
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Medicina de Precisão
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Recidiva Local de Neoplasia
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Aged
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Humans
Idioma:
En
Revista:
J Geriatr Oncol
Ano de publicação:
2018
Tipo de documento:
Article