New compounds with antimicrobial activities from Elaeodendron buchananii stem bark.
J Asian Nat Prod Res
; 20(6): 510-524, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29338355
ABSTRACT
The plant species Elaeodendron buchananii Loes is widely used in folklore medicine to manage microbial infections in Kenya. Previous studies on the plant fruits and root bark revealed the presence of steroids and terpenoids. The present phytochemical analysis of the plant stem bark has led to the isolation of four new triterpenes characterized as methyl 3ß-acetoxy-11α, 19α, 28-trihydroxyurs-12-en-23-oic acid (1), 3ß, 11α, 19α-trihydroxyurs-12-en-23, 28-dioic acid (2), 3ß-acetoxy-19α, 23, 28-trihydroxyurs-12-ene (3) and 3-oxo-19α, 28-dihydroxyurs-12-en-24-oic acid (4), together with ten known ones (5-14), whose structures were elucidated using spectroscopic techniques. The isolate canophyllol (8) showed promising antibacterial activity against N. meningitides with MIC value of 31.25 µg/ml.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Celastraceae
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Antibacterianos
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Antifúngicos
Idioma:
En
Revista:
J Asian Nat Prod Res
Ano de publicação:
2018
Tipo de documento:
Article