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Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia.
Morland, Cecilie; Frøland, Anne-Sofie; Pettersen, Mi Nguyen; Storm-Mathisen, Jon; Gundersen, Vidar; Rise, Frode; Hassel, Bjørnar.
Afiliação
  • Morland C; Norwegian Defense Research Establishment, Kjeller, Norway.
  • Frøland AS; Department of Anatomy and Centre for Molecular Biology and Neuroscience, University of Oslo, Oslo, Norway.
  • Pettersen MN; Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway.
  • Storm-Mathisen J; Norwegian Defense Research Establishment, Kjeller, Norway.
  • Gundersen V; Department of Complex Neurology and Neurohabilitation, Oslo University Hospital and University of Oslo, Oslo, Norway.
  • Rise F; Department of Chemistry, University of Oslo, Oslo, Norway.
  • Hassel B; Norwegian Defense Research Establishment, Kjeller, Norway.
Biochem J ; 475(4): 749-758, 2018 02 16.
Article em En | MEDLINE | ID: mdl-29339464
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propionatos / Letargia / Acidemia Propiônica / Neurônios GABAérgicos / 4-Aminobutirato Transaminase Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Biochem J Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propionatos / Letargia / Acidemia Propiônica / Neurônios GABAérgicos / 4-Aminobutirato Transaminase Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Biochem J Ano de publicação: 2018 Tipo de documento: Article