The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production.
ACS Chem Neurosci
; 9(10): 2307-2330, 2018 10 17.
Article
em En
| MEDLINE
| ID: mdl-29342356
ABSTRACT
Humankind has used and abused psychoactive drugs for millennia. Formally, a psychoactive drug is any agent that alters cognition and mood. The term "psychotropic drug" is neutral and describes the entire class of substrates, licit and illicit, of interest to governmental drug policy. While these drugs are prescribed for issues ranging from pain management to anxiety, they are also used recreationally. In fact, the current opioid epidemic is the deadliest drug crisis in American history. While the topic is highly politicized with racial, gender, and socioeconomic elements, there is no denying the toll drug mis- and overuse is taking on this country. Overdose, fueled by opioids, is the leading cause of death for Americans under 50 years of age, killing ca. 64,000 people in 2016. From a chemistry standpoint, the question is in what ways, if any, did organic chemists contribute to this problem? In this targeted review, we provide brief historical accounts of the main classes of psychoactive drugs and discuss several foundational total syntheses that ultimately provide the groundwork for producing these molecules in academic, industrial, and clandestine settings.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
8_ODS3_consumo_sustancias_psicoactivas
Base de dados:
MEDLINE
Assunto principal:
Psicotrópicos
/
Alcaloides Opiáceos
/
Alucinógenos
/
Estimulantes do Sistema Nervoso Central
País/Região como assunto:
America do norte
Idioma:
En
Revista:
ACS Chem Neurosci
Ano de publicação:
2018
Tipo de documento:
Article