Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease.
Carbohydr Polym
; 184: 342-353, 2018 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-29352928
The use of injectable hydrogel formulations have been suggested as a promising strategy for the treatment of degenerative disc disease to both restore the biomechanical function and reduce low back pain. In this work, a new thermo-sensitive injectable hydrogels with tunable thermo-sensitivity and enhanced stability were developed with N-hexanoylation of glycol chitosan (GC) for treatment of degenerative disc disease, and their physico-chemical and biological properties were evaluated. The sol-gel transition temperature of the hydrogels was controlled in a range of 23-56⯰С, depending on the degree of hexanoylation and the polymer concentration. In vitro and in vivo tests showed no cytotoxicity and no adverse effects in a rat model. The hydrogel filling of the defective IVD site in an ex vivo porcine model maintained its stability for longer than 28â¯days. These results suggest that the hydrogel can be used as an alternative material for treatment of disc herniation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrogéis
/
Quitosana
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Degeneração do Disco Intervertebral
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Deslocamento do Disco Intervertebral
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2018
Tipo de documento:
Article