Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats.
Arch Virol
; 163(4): 1073-1077, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29353423
ABSTRACT
Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-myc, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of myc transduction usable in clinical diagnosis. The assay targets c-myc exons 2 and 3, which together result in a FeLV-specific fusion gene following c-myc transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors, myc transduction was detected in 14% of T-cell lymphoma/leukemias. This newly established system could become a useful diagnostic tool in veterinary medicine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Viral
/
Reação em Cadeia da Polimerase
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Linfoma de Células T
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Proteínas Proto-Oncogênicas c-myc
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Leucemia Felina
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Vírus da Leucemia Felina
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Arch Virol
Ano de publicação:
2018
Tipo de documento:
Article