Racemic indole alkaloids from the seeds of Peganum harmala.
Fitoterapia
; 125: 155-160, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-29355750
ABSTRACT
Five pairs of new 2-oxoindole alkaloids, (±)-peganumalines A-E (1-5), and a new indole alkaloid, peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantum chemistry calculations. Notably, (±)-peganumalines A (1) represent a pair of rare 2-oxoindole dimeric alkaloid enantiomer with the hitherto unknown carbon skeleton. All isolates were tested for antiproliferative and antibacterial activities.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sementes
/
Alcaloides Indólicos
/
Peganum
Limite:
Humans
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2018
Tipo de documento:
Article