Sleep deprivation negatively impacts reproductive output in Drosophila melanogaster.
J Exp Biol
; 221(Pt 6)2018 03 26.
Article
em En
| MEDLINE
| ID: mdl-29361608
ABSTRACT
Most animals sleep or exhibit a sleep-like state, yet the adaptive significance of this phenomenon remains unclear. Although reproductive deficits are associated with lifestyle-induced sleep deficiencies, how sleep loss affects reproductive physiology is poorly understood, even in model organisms. We aimed to bridge this mechanistic gap by impairing sleep in female fruit flies and testing its effect on egg output. We found that sleep deprivation by feeding caffeine or by mechanical perturbation resulted in decreased egg output. Transient activation of wake-promoting dopaminergic neurons decreased egg output in addition to sleep levels, thus demonstrating a direct negative impact of sleep deficit on reproductive output. Similarly, loss-of-function mutation in dopamine transporter fumin (fmn) led to both significant sleep loss and lowered fecundity. This demonstration of a direct relationship between sleep and reproductive fitness indicates a strong driving force for the evolution of sleep.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oviposição
/
Privação do Sono
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Drosophila melanogaster
Limite:
Animals
Idioma:
En
Revista:
J Exp Biol
Ano de publicação:
2018
Tipo de documento:
Article