Magnesium attenuates endothelin-1-induced vasoreactivity and enhances vasodilatation in mouse pulmonary arteries: Modulation by chronic hypoxic pulmonary hypertension.

Mu, Yun-Ping; Huang, Qiu-Hong; Zhu, Jie-Ling; Zheng, Si-Yi; Yan, Fu-Rong; Zhuang, Xiao-Ling; Sham, James S K; Lin, Mo-Jun

Mu, Yun-Ping; Huang, Qiu-Hong; Zhu, Jie-Ling; Zheng, Si-Yi; Yan, Fu-Rong; Zhuang, Xiao-Ling; Sham, James S K; Lin, Mo-Jun.

Afiliação

Mu YP; The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou, Fujian, PR China.
Huang QH; Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, PR China.
Zhu JL; The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou, Fujian, PR China.
Zheng SY; Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, PR China.
Yan FR; The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou, Fujian, PR China.
Zhuang XL; Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, PR China.
Sham JSK; The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou, Fujian, PR China.
Lin MJ; Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, PR China.

Exp Physiol ; 103(4): 604-616, 2018 04 01.

Article em En | MEDLINE | ID: mdl-29363240

Assuntos

Endotelina-1/farmacologia; Hipertensão Pulmonar/tratamento farmacológico; Hipóxia/tratamento farmacológico; Magnésio/farmacologia; Artéria Pulmonar/efeitos dos fármacos; Vasodilatação/efeitos dos fármacos; Vasodilatadores/farmacologia; Animais; Endotélio Vascular/efeitos dos fármacos; Endotélio Vascular/metabolismo; Endotélio Vascular/fisiopatologia; Hipertensão Pulmonar/metabolismo; Hipertensão Pulmonar/fisiopatologia; Hipóxia/metabolismo; Hipóxia/fisiopatologia; Masculino; Camundongos; Camundongos Endogâmicos ICR; Músculo Liso Vascular/efeitos dos fármacos; Músculo Liso Vascular/metabolismo; Miócitos de Músculo Liso/efeitos dos fármacos; Miócitos de Músculo Liso/fisiologia; Óxido Nítrico/metabolismo; Artéria Pulmonar/metabolismo; Artéria Pulmonar/fisiopatologia; Vasoconstrição/efeitos dos fármacos; Vasoconstritores/farmacologia

Palavras-chave

chronic hypoxia; endothelin-1; magnesium; pulmonary hypertension; vasodilatation; vasoreactivity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artéria Pulmonar / Vasodilatação / Vasodilatadores / Endotelina-1 / Hipertensão Pulmonar / Magnésio / Hipóxia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Exp Physiol Ano de publicação: 2018 Tipo de documento: Article

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