Urinary beta-trace protein gene expression analysis in type 2 diabetes mellitus patients.
Einstein (Sao Paulo)
; 15(4): 441-444, 2017.
Article
em En, Pt
| MEDLINE
| ID: mdl-29364366
ABSTRACT
OBJECTIVE:
To evaluate the gene expression of beta-trace protein in urine of diabetic patients, with no reduction in glomerular filtration rate, which was defined as below 60mL/min/1.73m2.METHODS:
Type 2 diabetes mellitus patients were recruited, and a group of non-diabetic individuals served as control. Beta-trace protein gene expression was analyzed by quantitative PCR. Blood samples were collected to establish glucose levels and baseline kidney function. Accuracy was analyzed using ROC curves.RESULTS:
Ninety type 2 diabetes mellitus patients and 20 non-diabetic individuals were recruited. The area under the curve was 0.601, sensitivity of 20% and specificity of 89.47%. Among diabetic participants, 18% showed an expression above the cutoff point.CONCLUSION:
These results of accuracy of beta-trace protein gene expression in urine of diabetic patients are promising, although they did not achieve a higher area under the curve level.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases Intramoleculares
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Diabetes Mellitus Tipo 2
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Lipocalinas
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
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Prevalence_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
/
Pt
Revista:
Einstein (Sao Paulo)
Ano de publicação:
2017
Tipo de documento:
Article