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RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism.
Liu, Wenjing; Chen, Binbin; Wang, Yang; Meng, Chenling; Huang, Huihui; Huang, Xiao-Ru; Qin, Jinzhong; Mulay, Shrikant R; Anders, Hans-Joachim; Qiu, Andong; Yang, Baoxue; Freeman, Gordon J; Lu, Hua Jenny; Lin, Herbert Y; Zheng, Zhi-Hua; Lan, Hui-Yao; Huang, Yu; Xia, Yin.
Afiliação
  • Liu W; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Chen B; School of Medicine, Yunnan University, Kunming, Yunnan 650091, China.
  • Wang Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Meng C; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Huang H; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Huang XR; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Qin J; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
  • Mulay SR; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210014, China.
  • Anders HJ; Medizinische Klinik und Poliklinik IV, Klinikum der Universität, München, Munich 80336, Germany.
  • Qiu A; Medizinische Klinik und Poliklinik IV, Klinikum der Universität, München, Munich 80336, Germany.
  • Yang B; School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Freeman GJ; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
  • Lu HJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Lin HY; Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Zheng ZH; Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Lan HY; Department of Nephrology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
  • Huang Y; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
  • Xia Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Proc Natl Acad Sci U S A ; 115(7): E1475-E1484, 2018 02 13.
Article em En | MEDLINE | ID: mdl-29382757

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Traumatismo por Reperfusão / Apoptose / Injúria Renal Aguda / Túbulos Renais / Necrose / Proteínas do Tecido Nervoso Tipo de estudo: Etiology_studies / Guideline Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Traumatismo por Reperfusão / Apoptose / Injúria Renal Aguda / Túbulos Renais / Necrose / Proteínas do Tecido Nervoso Tipo de estudo: Etiology_studies / Guideline Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2018 Tipo de documento: Article