The Neurobiology of d-Serine Signaling.
Adv Pharmacol
; 82: 325-348, 2018.
Article
em En
| MEDLINE
| ID: mdl-29413526
ABSTRACT
d-Serine is a physiological coagonist of NMDA receptors involved in synaptic plasticity, neurodevelopment, and neurodegeneration. d-Serine is synthesized by the enzyme serine racemase, which converts l- to d-serine. Recent studies indicate that the supply of l-serine by astroglia fuels the neuronal synthesis of d-serine. This pathway, named the serine shuttle, highlights the importance of the glia-neuron metabolic crosstalk for regulating NMDA receptor activity. Dysfunction of different components of the serine shuttle pathway leads to neurodevelopmental defects, neurodegeneration, and may be involved in psychiatric diseases. Serine racemase and other components of the serine shuttle are therefore promising targets for neuroprotective drugs. Here we review several aspects of the neurobiology of d-serine focusing on mechanisms regulating d-serine signaling in health and disease.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Serina
/
Transdução de Sinais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Pharmacol
Ano de publicação:
2018
Tipo de documento:
Article