HMGB1 silencing in macrophages prevented their functional skewing and ameliorated EAM development: Nuclear HMGB1 may be a checkpoint molecule of macrophage reprogramming.

Jiang, Yuanyuan; Chen, Rong; Shao, Xiaoyi; Ji, Xiaoyun; Lu, Hongxiang; Zhou, Shanshan; Zong, Gangjun; Xu, Huaxi; Su, Zhaoliang

Jiang, Yuanyuan; Chen, Rong; Shao, Xiaoyi; Ji, Xiaoyun; Lu, Hongxiang; Zhou, Shanshan; Zong, Gangjun; Xu, Huaxi; Su, Zhaoliang.

Afiliação

Jiang Y; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Chen R; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Shao X; Department of Immunology, Jiangsu University, Zhenjiang 212013, China; Department of Cardiology, Wuxi Clinical Hospital, Anhui Medical University, Wuxi, Jiangsu Province 214000, China.
Ji X; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Lu H; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Zhou S; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Zong G; Department of Cardiology, Wuxi Clinical Hospital, Anhui Medical University, Wuxi, Jiangsu Province 214000, China. Electronic address: zonggj@163.com.
Xu H; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Su Z; Department of Immunology, Jiangsu University, Zhenjiang 212013, China. Electronic address: szl30@ujs.edu.cn.

Int Immunopharmacol ; 56: 277-284, 2018 Mar.

Article em En | MEDLINE | ID: mdl-29414662

Assuntos

Encefalomielite Autoimune Experimental/imunologia; Proteína HMGB1/metabolismo; Macrófagos/imunologia; Esclerose Múltipla/imunologia; Animais; Autoantígenos/imunologia; Miosinas Cardíacas/imunologia; Diferenciação Celular; Reprogramação Celular; Citocinas/metabolismo; Modelos Animais de Doenças; Progressão da Doença; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Proteína HMGB1/genética; Humanos; Sistema de Sinalização das MAP Quinases; Camundongos; Camundongos Endogâmicos BALB C; Cadeias Pesadas de Miosina/imunologia; NF-kappa B/metabolismo; Células RAW 264.7; RNA Interferente Pequeno/genética; Células Th1/imunologia

Palavras-chave

Angiotensin II; EAM; HMGB1; Macrophage reprogramming

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína HMGB1 / Encefalomielite Autoimune Experimental / Macrófagos / Esclerose Múltipla Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Int Immunopharmacol Ano de publicação: 2018 Tipo de documento: Article

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