Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain.

Neuhaus, Winfried; Piontek, Anna; Protze, Jonas; Eichner, Miriam; Mahringer, Anne; Subileau, Eva-Anne; Lee, In-Fah M; Schulzke, Jörg D; Krause, Gerd; Piontek, Jörg

Neuhaus, Winfried; Piontek, Anna; Protze, Jonas; Eichner, Miriam; Mahringer, Anne; Subileau, Eva-Anne; Lee, In-Fah M; Schulzke, Jörg D; Krause, Gerd; Piontek, Jörg.

Afiliação

Neuhaus W; AIT Austrian Institute of Technology GmbH, Center Health and Bioresources, Unit Molecular Diagnostics, Vienna, Austria.
Piontek A; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Protze J; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Eichner M; Institute of Clinical Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Mahringer A; Department of Pharmaceutical Technology and Biopharmacy, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany.
Subileau EA; Biopredic International, Rennes, France.
Lee IM; Institute of Clinical Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Schulzke JD; Institute of Clinical Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Krause G; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. Electronic address: GKrause@fmp-berlin.de.
Piontek J; Institute of Clinical Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Biomaterials ; 161: 129-143, 2018 04.

Article em En | MEDLINE | ID: mdl-29421550

Assuntos

Barreira Hematoencefálica/metabolismo; Claudina-5/metabolismo; Clostridium perfringens/metabolismo; Enterotoxinas/metabolismo; Animais; Transporte Biológico; Barreira Hematoencefálica/ultraestrutura; Encéfalo/metabolismo; Encéfalo/ultraestrutura; Células Cultivadas; Células Endoteliais/metabolismo; Enterotoxinas/química; Técnica de Fratura por Congelamento; Células HEK293; Humanos; Microscopia Eletrônica; Ligação Proteica; Suínos; Junções Íntimas/metabolismo; Junções Íntimas/ultraestrutura

Palavras-chave

Blood brain barrier; Claudin; Clostridium perfringens enterotoxin; Paracellular drug delivery; Tight junction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Clostridium perfringens / Enterotoxinas / Claudina-5 Limite: Animals / Humans Idioma: En Revista: Biomaterials Ano de publicação: 2018 Tipo de documento: Article

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