Population pharmacokinetics/pharmacodynamics of linezolid in sepsis patients with and without continuous renal replacement therapy.

Ide, Takeshi; Takesue, Yoshio; Ikawa, Kazuro; Morikawa, Norifumi; Ueda, Takashi; Takahashi, Yoshiko; Nakajima, Kazuhiko; Takeda, Kenta; Nishi, Shinichi

Ide, Takeshi; Takesue, Yoshio; Ikawa, Kazuro; Morikawa, Norifumi; Ueda, Takashi; Takahashi, Yoshiko; Nakajima, Kazuhiko; Takeda, Kenta; Nishi, Shinichi.

Afiliação

Ide T; Division of Intensive Care Unit, Hyogo College of Medicine, Hyogo, Japan. Electronic address: tide@hyo-med.ac.jp.
Takesue Y; Department of Infection Control and Prevention, Hyogo College of Medicine, Hyogo, Japan.
Ikawa K; Department of Clinical Pharmacotherapy, Hiroshima University, Hiroshima, Japan.
Morikawa N; Department of Clinical Pharmacotherapy, Hiroshima University, Hiroshima, Japan.
Ueda T; Department of Infection Control and Prevention, Hyogo College of Medicine, Hyogo, Japan.
Takahashi Y; Department of Pharmacy, The Hospital of Hyogo College of Medicine, Hyogo, Japan.
Nakajima K; Department of Infection Control and Prevention, Hyogo College of Medicine, Hyogo, Japan.
Takeda K; Division of Intensive Care Unit, Hyogo College of Medicine, Hyogo, Japan.
Nishi S; Division of Intensive Care Unit, Hyogo College of Medicine, Hyogo, Japan.

Int J Antimicrob Agents ; 51(5): 745-751, 2018 May.

Article em En | MEDLINE | ID: mdl-29425834

Assuntos

Antibacterianos/farmacocinética; Linezolida/farmacocinética; Terapia de Substituição Renal/métodos; Sepse/tratamento farmacológico; Idoso; Idoso de 80 Anos ou mais; Antibacterianos/administração & dosagem; Antibacterianos/sangue; Área Sob a Curva; Humanos; Rim/fisiopatologia; Linezolida/administração & dosagem; Linezolida/sangue; Pessoa de Meia-Idade; Método de Monte Carlo; Estudos Prospectivos; Infecções Estafilocócicas/tratamento farmacológico

Palavras-chave

Linezolid; Methicillin-resistant Staphylococcus aureus; Monte Carlo simulation; Pharmacokinetics/pharmacodynamics; Sepsis

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Terapia de Substituição Renal / Sepse / Linezolida / Antibacterianos Tipo de estudo: Health_economic_evaluation / Observational_studies / Prognostic_studies Limite: Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Int J Antimicrob Agents Ano de publicação: 2018 Tipo de documento: Article

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