Anti-inflammatory activity and gastroprotective effect of Hertia cheirifolia L. roots extract.
J Ethnopharmacol
; 217: 7-10, 2018 May 10.
Article
em En
| MEDLINE
| ID: mdl-29428240
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Hertia cheirifolia L. is used traditionally to treat rheumatic pains and known as a medicinal plant having several pharmaceutical and biological activities. The present study evaluated in vivo the anti-inflammatory and gastroprotective effects of the methanolic extract from H. cheirifolia L. MATERIALS AND METHODS:
Reverse phase high-performance liquid chromatography (RP-HPLC) was performed to identify various chemical components of the plant extract. Anti-inflammatory and gastroprotective activities were assessed on carrageenan-induced paw edema and HCl/ethanol-induced gastric lesions in rats, respectively.RESULTS:
(RP-HPLC) analysis indicated that coumarin is the abundant component in the extract (53.80%). Intraperitoneal administration of the methanolic extract at different doses showed interesting activities in rats in a dose-dependent manner. At 100â¯mg/kg, this extract showed the highest acute anti-inflammatory activity and an important inhibition of gastric lesions with inhibition percentage of 79.41% and 88.53%, respectively.CONCLUSION:
Altogether, the results of this study reveal the anti-inflammatory and gastroprotective effects of H. cheirifolia extract and promote the traditional use of this plant in the treatment of different pain and inflammatory diseases.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Úlcera Gástrica
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Extratos Vegetais
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Raízes de Plantas
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Asteraceae
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Edema
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Anti-Inflamatórios
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Antiulcerosos
Limite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2018
Tipo de documento:
Article