Curcumin inspired 2-chloro/phenoxy quinoline analogues: Synthesis and biological evaluation as potential anticancer agents.

Sri Ramya, P V; Guntuku, Lalita; Angapelly, Srinivas; Karri, Shailaja; Digwal, Chander Singh; Babu, Bathini Nagendra; Naidu, V G M; Kamal, Ahmed

Sri Ramya, P V; Guntuku, Lalita; Angapelly, Srinivas; Karri, Shailaja; Digwal, Chander Singh; Babu, Bathini Nagendra; Naidu, V G M; Kamal, Ahmed.

Afiliação

Sri Ramya PV; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Guntuku L; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Angapelly S; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Karri S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Digwal CS; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Babu BN; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Naidu VGM; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Kamal A; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India; School of Pharmaceutical Education and Research (SPER), Jamia Hamdard University, New Delhi 110062, India. Electronic address: ahmedkamal@iict.res.in.

Bioorg Med Chem Lett ; 28(5): 892-898, 2018 03 01.

Article em En | MEDLINE | ID: mdl-29429834

Assuntos

Antineoplásicos/farmacologia; Curcumina/farmacologia; Quinolinas/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Curcumina/química; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Estrutura Molecular; Quinolinas/química; Relação Estrutura-Atividade

Palavras-chave

2-Substituted quinolines; Anticancer; Apoptosis; Claisen-Schmidt condensation; Curcumin mimics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Curcumina / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2018 Tipo de documento: Article

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