Comparative effect of antipsychotics on risk of self-harm among patients with schizophrenia.
Acta Psychiatr Scand
; 137(4): 296-305, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29430641
ABSTRACT
OBJECTIVE:
To investigate the association of different antipsychotic treatments with hospitalization due to self-harm among patients with schizophrenia.METHOD:
This retrospective cohort study was based on Taiwan's universal health insurance database. Patients aged 15-45 years with a newly diagnosed schizophrenic disorder in 2001-2012 were included. The study outcome was the first hospitalization due to self-harm or undetermined injury after the diagnosis of schizophrenic disorders. The exposure status of antipsychotics was modeled as a time-dependent variable. The analyses were stratified by antipsychotic dosage based on defined daily dose (DDD).RESULTS:
Among 70 380 patients with a follow-up of 500 355 person-years, 2272 self-harm hospitalization episodes were identified. Compared with none or former use, current use of several second-generation antipsychotics with a dose of one DDD or above, including amisulpride, aripiprazole, clozapine, risperidone, and sulpiride, was associated with decreased risk of self-harm hospitalization, with clozapine showing the strongest effect (adjusted rate ratio = 0.26, 95% confidence interval 0.15-0.47).CONCLUSION:
The protective effect on self-harm may vary across different antipsychotics. Further studies are needed to replicate the findings.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Antipsicóticos
/
Comportamento Autodestrutivo
/
Clozapina
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
2018
Tipo de documento:
Article