Metaplastic Cdx2-depleted cells can be very disruptive neighbors.

Lourenço, Filipe C; Winton, Douglas J

Lourenço, Filipe C; Winton, Douglas J.

Afiliação

Lourenço FC; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, England, UK Filipe.Lourenco@cruk.cam.ac.uk.
Winton DJ; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, England, UK Doug.Winton@cruk.cam.ac.uk.

J Exp Med ; 215(3): 725-727, 2018 03 05.

Article em En | MEDLINE | ID: mdl-29440363

ABSTRACT

ABSTRACT

In this issue of JEM, Balbinot et al. (https//doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring "normal" Cdx2-positive cells.

Assuntos

Genes Homeobox; Proteínas de Homeodomínio/genética; Animais; Fator de Transcrição CDX2; Carcinogênese; Camundongos; Camundongos Transgênicos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genes Homeobox / Proteínas de Homeodomínio Limite: Animals Idioma: En Revista: J Exp Med Ano de publicação: 2018 Tipo de documento: Article

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