Copper-Catalyzed C(sp)-C(sp3) Coupling of Terminal Alkynes with Alkylsilyl Peroxides via a Radical Mechanism.
Org Lett
; 20(5): 1400-1403, 2018 03 02.
Article
em En
| MEDLINE
| ID: mdl-29450996
ABSTRACT
A copper-catalyzed C(sp)-C(sp3) coupling reaction between terminal alkynes and alkylsilyl peroxides is reported. In the presence of a copper catalyst and 4-dimethylaminopyridine, the reaction smoothly affords a variety of internal alkynes by coupling alkylsilyl peroxides and terminal alkynes. Mechanistic studies suggest that the reaction proceeds via a radical mechanism, whereby the alkyl radicals are generated from the alkylsilyl peroxides. The present transformation represents a rare example of a radical-mediated C(sp)-C(sp3) coupling reaction of terminal alkynes.
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01-internacional
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MEDLINE
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2018
Tipo de documento:
Article