Autoantibodies Hurt: Transfer of Patient-Derived CASPR2 Antibodies Induces Neuropathic Pain in Mice.

Hunt, Matthew A; Nascimento, Diana S M; Bersellini Farinotti, Alex; Svensson, Camilla I

Hunt, Matthew A; Nascimento, Diana S M; Bersellini Farinotti, Alex; Svensson, Camilla I.

Afiliação

Hunt MA; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Nascimento DSM; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Bersellini Farinotti A; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Svensson CI; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: camilla.svensson@ki.se.

Neuron ; 97(4): 729-731, 2018 02 21.

Article em En | MEDLINE | ID: mdl-29470963

RESUMO

In this issue of Neuron, Dawes et al. (2018) show that CASPR2 antibodies (Abs) isolated from patients bind specifically to primary afferent cell bodies and induce neuropathic pain in mice. Consequent decreased expression of Kv1 channels and their aberrant localization along myelinated axons explain the observed hyperexcitability and pain.

Assuntos

Autoanticorpos; Neuralgia; Animais; Axônios; Humanos; Proteínas de Membrana; Camundongos; Proteínas do Tecido Nervoso

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Neuralgia Limite: Animals / Humans Idioma: En Revista: Neuron Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google