Pleuroparenchymal fibroelastosis with positive MPO-ANCA diagnosed with a CT-guided percutaneous needle biopsy.
BMJ Case Rep
; 20182018 Feb 24.
Article
em En
| MEDLINE
| ID: mdl-29478005
ABSTRACT
A 67-year-old woman was referred to our hospital because of gradually increasing dyspnoea on exertion for 6 months. Chest CT scan showed subpleural parenchymal fibrotic opacities with traction bronchiectasis in the bilateral upper lung fields. Serum rheumatoid factor and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) were positive. There was no evident reason to suspect connective tissue disease such as ANCA-associated vasculitis or rheumatoid arthritis. We performed a CT-guided percutaneous needle biopsy of the subpleural lesion that showed slight uptake on the fluorodeoxyglucose-positron emission tomography (FDG-PET) CT scan. This specimen showed subpleural fibrosis as evidenced by an abnormal increase of elastic tissue and minimal collagen deposition, which indicated pleuroparenchymal fibroelastosis (PPFE). Although PPFE can be associated with a variety of causes, its association with MPO-ANCA is unknown. A CT-guided transthoracic lung biopsy caused no adverse events and was useful in the diagnosis of PPFE in our patient.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pleuropneumonia
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Fibrose Pulmonar
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Tomografia Computadorizada por Raios X
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Radiografia Intervencionista
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Peroxidase
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Anticorpos Anticitoplasma de Neutrófilos
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
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Female
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Humans
Idioma:
En
Revista:
BMJ Case Rep
Ano de publicação:
2018
Tipo de documento:
Article