A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling.

Romano, Gabriele; Chen, Pei-Ling; Song, Ping; McQuade, Jennifer L; Liang, Roger J; Liu, Mingguang; Roh, Whijae; Duose, Dzifa Y; Carapeto, Fernando C L; Li, Jun; Teh, Jessica L F; Aplin, Andrew E; Chen, Merry; Zhang, Jianhua; Lazar, Alexander J; Davies, Michael A; Futreal, P Andrew; Amaria, Rodabe N; Zhang, David Y; Wargo, Jennifer A; Kwong, Lawrence N

A Preexisting Rare PIK3CA^E545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling.

Romano, Gabriele; Chen, Pei-Ling; Song, Ping; McQuade, Jennifer L; Liang, Roger J; Liu, Mingguang; Roh, Whijae; Duose, Dzifa Y; Carapeto, Fernando C L; Li, Jun; Teh, Jessica L F; Aplin, Andrew E; Chen, Merry; Zhang, Jianhua; Lazar, Alexander J; Davies, Michael A; Futreal, P Andrew; Amaria, Rodabe N; Zhang, David Y; Wargo, Jennifer A; Kwong, Lawrence N.

Afiliação

Romano G; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Chen PL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Song P; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
McQuade JL; Department of Bioengineering, Rice University, Houston, Texas.
Liang RJ; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Liu M; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Roh W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Duose DY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Carapeto FCL; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Li J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Teh JLF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Aplin AE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Chen M; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Zhang J; Department of Cutaneous Biology and Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Lazar AJ; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Davies MA; Department of Neurooncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Amaria RN; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Zhang DY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Wargo JA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Kwong LN; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Cancer Discov ; 8(5): 556-567, 2018 05.

Article em En | MEDLINE | ID: mdl-29496665

Assuntos

Classe I de Fosfatidilinositol 3-Quinases/genética; Resistencia a Medicamentos Antineoplásicos/genética; GTP Fosfo-Hidrolases/genética; Melanoma/genética; Melanoma/metabolismo; Proteínas de Membrana/genética; Mutação; Proteínas Quinases S6 Ribossômicas 70-kDa/metabolismo; Transdução de Sinais; Animais; Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Biomarcadores; Linhagem Celular Tumoral; Classe I de Fosfatidilinositol 3-Quinases/metabolismo; Quinase 4 Dependente de Ciclina/antagonistas & inibidores; Quinase 6 Dependente de Ciclina/antagonistas & inibidores; Feminino; GTP Fosfo-Hidrolases/metabolismo; Humanos; Melanoma/diagnóstico; Melanoma/tratamento farmacológico; Proteínas de Membrana/metabolismo; Camundongos; Pessoa de Meia-Idade; Modelos Biológicos; Fosforilação; Tomografia por Emissão de Pósitrons; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico; Transdução de Sinais/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Resistencia a Medicamentos Antineoplásicos / Proteínas Quinases S6 Ribossômicas 70-kDa / Classe I de Fosfatidilinositol 3-Quinases / GTP Fosfo-Hidrolases / Melanoma / Proteínas de Membrana / Mutação Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans / Middle aged Idioma: En Revista: Cancer Discov Ano de publicação: 2018 Tipo de documento: Article

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