Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner.

Datta, Moumita; Staszewski, Ori; Raschi, Elena; Frosch, Maximilian; Hagemeyer, Nora; Tay, Tuan Leng; Blank, Thomas; Kreutzfeldt, Mario; Merkler, Doron; Ziegler-Waldkirch, Stephanie; Matthias, Patrick; Meyer-Luehmann, Melanie; Prinz, Marco

Datta, Moumita; Staszewski, Ori; Raschi, Elena; Frosch, Maximilian; Hagemeyer, Nora; Tay, Tuan Leng; Blank, Thomas; Kreutzfeldt, Mario; Merkler, Doron; Ziegler-Waldkirch, Stephanie; Matthias, Patrick; Meyer-Luehmann, Melanie; Prinz, Marco.

Afiliação

Datta M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany. Electronic address: moumita.datta@uni-ulm.de.
Staszewski O; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Raschi E; Department of Experimental, Diagnostic and Speciality Medicine, School of Medicine, Alma Mater Studiorum University of Bologna, Bologna 40126, Italy.
Frosch M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Hagemeyer N; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Tay TL; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Blank T; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Kreutzfeldt M; Department of Pathology and Immunology, Geneva Faculty of Medicine, Geneva 1211, Switzerland.
Merkler D; Department of Pathology and Immunology, Geneva Faculty of Medicine, Geneva 1211, Switzerland.
Ziegler-Waldkirch S; Department of Neurology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Matthias P; Friedrich Miescher Institute for Biomedical Research, Basel 4002, Switzerland.
Meyer-Luehmann M; Department of Neurology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Prinz M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg 79104, Germany. Electronic address: marco.prinz@uniklinik-freiburg.de.

Immunity ; 48(3): 514-529.e6, 2018 03 20.

Article em En | MEDLINE | ID: mdl-29548672

Assuntos

Histona Desacetilase 1/genética; Histona Desacetilase 2/genética; Homeostase; Microglia/imunologia; Microglia/metabolismo; Doenças Neurodegenerativas/genética; Neurogênese/genética; Animais; Apoptose; Proliferação de Células; Modelos Animais de Doenças; Epigênese Genética; Expressão Gênica; Perfilação da Expressão Gênica; Regulação da Expressão Gênica; Histona Desacetilase 1/metabolismo; Histona Desacetilase 2/metabolismo; Histonas/metabolismo; Transtornos da Memória/genética; Transtornos da Memória/metabolismo; Camundongos; Camundongos Knockout; Camundongos Transgênicos; Doenças Neurodegenerativas/metabolismo; Doenças Neurodegenerativas/patologia; Doenças Neurodegenerativas/psicologia; Neurogênese/imunologia; Fagocitose/imunologia; Placa Amiloide/genética; Placa Amiloide/metabolismo; Placa Amiloide/patologia; Aprendizagem Espacial; Transcriptoma

Palavras-chave

Alzheimer's disease; HDACs; epigenetics; microglia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglia / Doenças Neurodegenerativas / Neurogênese / Histona Desacetilase 1 / Histona Desacetilase 2 / Homeostase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Immunity Ano de publicação: 2018 Tipo de documento: Article

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