Creatine kinase level and its relationship with quantitative electromyographic characteristics in amyotrophic lateral sclerosis.
Clin Neurophysiol
; 129(5): 926-930, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29550653
ABSTRACT
OBJECTIVE:
To explore the relationship between serum creatine kinase (CK) level and electromyographic characteristics in patients with amyotrophic lateral sclerosis (ALS).METHODS:
Two hundred thirty-eight consecutive ALS patients were enrolled. All patients underwent electrophysiological study with a consistent approach. We calculated a compound muscle action potential (CMAP) sum score, and spontaneous potentials were graded from 0 to 4 depending on their density and distribution. We tested for any independent correlation of the CK levels with CMAP sum score, mean spontaneous potential (MSP) score, F wave persistence or conduction velocity.RESULTS:
The median serum CK level was 151 U/L. Log CK was independently correlated with MSP score (ßâ¯=â¯0.07, 95% CI 0.01-0.14, pâ¯=â¯0.032) and F persistence (ßâ¯=â¯-0.0013, 95% CI -0.00251 to -0.0002, pâ¯=â¯0.02) but not with CMAP sum score or F wave conduction velocity. When stratified by sex, the correlation of log CK with MSP score and F persistence was significant in male but not female patients.CONCLUSIONS:
The results support that lower motor neuron loss and muscle denervation are associated with elevated CK levels of ALS patients.SIGNIFICANCE:
The severity of lower motor neuron loss and denervation might be involved in pathophysiological mechanisms of CK elevation in ALS patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Músculo Esquelético
/
Creatina Quinase
/
Esclerose Lateral Amiotrófica
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Clin Neurophysiol
Ano de publicação:
2018
Tipo de documento:
Article