DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins.

Patel, Anamika; Yang, Peng; Tinkham, Matthew; Pradhan, Mihika; Sun, Ming-An; Wang, Yixuan; Hoang, Don; Wolf, Gernot; Horton, John R; Zhang, Xing; Macfarlan, Todd; Cheng, Xiaodong

Patel, Anamika; Yang, Peng; Tinkham, Matthew; Pradhan, Mihika; Sun, Ming-An; Wang, Yixuan; Hoang, Don; Wolf, Gernot; Horton, John R; Zhang, Xing; Macfarlan, Todd; Cheng, Xiaodong.

Afiliação

Patel A; Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA.
Yang P; The Eunice Kennedy Shriver National Institutes of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Tinkham M; The Eunice Kennedy Shriver National Institutes of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Pradhan M; Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA.
Sun MA; The Eunice Kennedy Shriver National Institutes of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Wang Y; The Eunice Kennedy Shriver National Institutes of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Hoang D; The Eunice Kennedy Shriver National Institutes of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Wolf G; The Eunice Kennedy Shriver National Institutes of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Horton JR; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Zhang X; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Macfarlan T; The Eunice Kennedy Shriver National Institutes of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. Electronic address: todd.macfarlan@nih.gov.
Cheng X; Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: xcheng5@mdanderson.org.

Cell ; 173(1): 221-233.e12, 2018 03 22.

Article em En | MEDLINE | ID: mdl-29551271

Assuntos

DNA/metabolismo; Proteínas Nucleares/metabolismo; Sequência de Aminoácidos; Animais; Sequência de Bases; Sítios de Ligação; Proteínas de Transporte/química; Proteínas de Transporte/classificação; Proteínas de Transporte/genética; Proteínas de Transporte/metabolismo; DNA/química; Humanos; Fator de Crescimento Insulin-Like II/química; Fator de Crescimento Insulin-Like II/genética; Fator de Crescimento Insulin-Like II/metabolismo; Camundongos; Simulação de Dinâmica Molecular; Proteínas Nucleares/química; Proteínas Nucleares/classificação; Proteínas Nucleares/genética; Conformação de Ácido Nucleico; Pan troglodytes; Filogenia; Polimorfismo de Nucleotídeo Único; Ligação Proteica; Estrutura Terciária de Proteína; Proteínas Recombinantes/biossíntese; Proteínas Recombinantes/química; Proteínas Recombinantes/isolamento & purificação; Alinhamento de Sequência

Palavras-chave

AT-rich; C2H2 zinc fingers; DNA conformation; Igf2; KRAB; Zfp568; imprinting; shortened minor groove

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Proteínas Nucleares Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article

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