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Current status, challenges and perspectives in the development of vaccines against yellow fever, dengue, Zika and chikungunya viruses.
Silva, José V J; Lopes, Thaísa R R; Oliveira-Filho, Edmilson F de; Oliveira, Renato A S; Durães-Carvalho, Ricardo; Gil, Laura H V G.
Afiliação
  • Silva JVJ; Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, PE, Brazil.
  • Lopes TRR; Virology Sector, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, PE, Brazil.
  • Oliveira-Filho EF; Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, PE, Brazil.
  • Oliveira RAS; Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, PE, Brazil; Departament of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE, Brazil.
  • Durães-Carvalho R; Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, PE, Brazil.
  • Gil LHVG; Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, PE, Brazil. Electronic address: laura@cpqam.fiocruz.br.
Acta Trop ; 182: 257-263, 2018 Jun.
Article em En | MEDLINE | ID: mdl-29551394
Emerging and re-emerging viral infections transmitted by insect vectors (arthopode-borne viruses, arbovirus) are a serious threat to global public health. Among them, yellow fever (YFV), dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses are particularly important in tropical and subtropical regions. Although vector control is one of the most used prophylactic measures against arboviruses, it often faces obstacles, such as vector diversity, uncontrolled urbanization and increasing resistance to insecticides. In this context, vaccines may be the best control strategy for arboviral diseases. Here, we provide a general overview about licensed vaccines and the most advanced vaccine candidates against YFV, DENV, CHIKV and ZIKV. In particular, we highlight vaccine difficulties, the current status of the most advanced strategies and discuss how the molecular characteristics of each virus can influence the choice of the different vaccine formulations.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Arbovírus / Vacinas Virais / Vírus Chikungunya / Vírus da Dengue / Zika virus Limite: Animals / Humans Idioma: En Revista: Acta Trop Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Arbovírus / Vacinas Virais / Vírus Chikungunya / Vírus da Dengue / Zika virus Limite: Animals / Humans Idioma: En Revista: Acta Trop Ano de publicação: 2018 Tipo de documento: Article