Comparative studies on the human serum albumin binding of the clinically approved EGFR inhibitors gefitinib, erlotinib, afatinib, osimertinib and the investigational inhibitor KP2187.

Dömötör, Orsolya; Pelivan, Karla; Borics, Attila; Keppler, Bernhard K; Kowol, Christian R; Enyedy, Éva A

Dömötör, Orsolya; Pelivan, Karla; Borics, Attila; Keppler, Bernhard K; Kowol, Christian R; Enyedy, Éva A.

Afiliação

Dömötör O; Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7. H-6720, Szeged, Hungary.
Pelivan K; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria.
Borics A; Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62. H-6726, Szeged, Hungary.
Keppler BK; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria; Research Cluster "Translational Cancer Therapy Research", University of Vienna and Medical University of Vienna, Vienna, Austria.
Kowol CR; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria; Research Cluster "Translational Cancer Therapy Research", University of Vienna and Medical University of Vienna, Vienna, Austria. Electronic address: christian.kowol@univie.ac.
Enyedy ÉA; Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7. H-6720, Szeged, Hungary. Electronic address: enyedy@chem.u-szeged.hu.

J Pharm Biomed Anal ; 154: 321-331, 2018 May 30.

Article em En | MEDLINE | ID: mdl-29567575

Assuntos

Receptores ErbB/metabolismo; Cloridrato de Erlotinib/farmacologia; Piperazinas/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Quinazolinas/farmacologia; Albumina Sérica Humana/metabolismo; Acrilamidas; Afatinib; Compostos de Anilina; Sítios de Ligação; Gefitinibe; Humanos; Ligação de Hidrogênio; Simulação de Acoplamento Molecular; Ligação Proteica; Solventes/química; Espectrometria de Fluorescência/métodos

Palavras-chave

Albumin binding; Binding constants; EGFR; Spectrofluorometry; Tyrosine kinase inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Quinazolinas / Inibidores de Proteínas Quinases / Receptores ErbB / Cloridrato de Erlotinib / Albumina Sérica Humana Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2018 Tipo de documento: Article

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