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Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid ß-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease.
Raefsky, Sophia M; Furman, Ran; Milne, Ginger; Pollock, Erik; Axelsen, Paul; Mattson, Mark P; Shchepinov, Mikhail S.
Afiliação
  • Raefsky SM; Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD.
  • Furman R; Departments of Pharmacology, Biochemistry and Biophysics, and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA.
  • Milne G; Eicosanoid Core Laboratory, Vanderbilt University Medical Center, Nashville, TN.
  • Pollock E; Stable Isotope Laboratory, University of Arkansas, Fayetteville, AR.
  • Axelsen P; Departments of Pharmacology, Biochemistry and Biophysics, and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA.
  • Mattson MP; Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: mark.mattson@nih.gov.
  • Shchepinov MS; Retrotope, Los Altos, CA.
Neurobiol Aging ; 66: 165-176, 2018 06.
Article em En | MEDLINE | ID: mdl-29579687
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Peroxidação de Lipídeos / Peptídeos beta-Amiloides / Ácidos Graxos Insaturados / Doença de Alzheimer / Hipocampo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurobiol Aging Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Peroxidação de Lipídeos / Peptídeos beta-Amiloides / Ácidos Graxos Insaturados / Doença de Alzheimer / Hipocampo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurobiol Aging Ano de publicação: 2018 Tipo de documento: Article