Roles of T follicular helper cells in the pathogenesis of adenoidal hypertrophy combined with secretory otitis media.
Medicine (Baltimore)
; 97(13): e0211, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-29595664
ABSTRACT
The aim of this study was to investigate the roles of T follicular helper (Tfh) cells in secretory otitis media (SOM) combined with adenoidal hypertrophy (AH).Patients with AH or AH combined with SOM admitted to the Yancheng No. 1 People's Hospital from December 2012 to December 2014 were included. Fourteen age-matched healthy individuals received physical examinations in the hospital served as control. The venous Tfh was determined using flow cytometry, and CD3â+âCD4â+âCXCR5â+âT lymphocytes were defined as Tfh cells. Serum inflammatory factors including IL-8, IL-1b, IL-6, IL-10, TNF, IL-12p70, IL-21, and IgE were determined using commercial kits.Compared with the AH group, the number of CD4â+âCXCR5â+âT cells in peripheral blood of the AH combined with SOM group showed significant increase. Statistical differences were noticed in the number of the number of CD4â+âCXCR5â+âT cells in moderate and severe AH groups compared with that of the control group. Statistical differences were identified in the proportion of CD4â+âCXCR5â+âT cells in the adenoidal tissues between the AH combined with SOM group and AH group (Pâ<â.05). For the CD4â+âCXCR5â+âT cells in adenoidal tissues, no statistical differences were noticed between the moderate and severe AH groups (Pâ>â.05). The number of CD4â+âCXCR5â+âT cells was positively correlated to the serum IL-21. Nevertheless, no correlation was noticed between CD4â+âCXCR5â+âT cell and serum IL-8, IL-6, IL-10, and IgE.Tfh is involved in the AH combined with SOM in children. Besides, serum IL-21, IL-8, IL-6, IL-10, and IgE may be involved in the onset of SOM in children.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Otite Média com Derrame
/
Doenças Nasofaríngeas
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Linfócitos T Auxiliares-Indutores
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Mediadores da Inflamação
Tipo de estudo:
Etiology_studies
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Prognostic_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2018
Tipo de documento:
Article