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Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086.
Liu, Cong-Cong; Zhang, Zhen-Zhen; Feng, Yan-Yan; Gu, Qian-Qun; Li, De-Hai; Zhu, Tian-Jiao.
Afiliação
  • Liu CC; a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , P. R. China.
  • Zhang ZZ; a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , P. R. China.
  • Feng YY; a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , P. R. China.
  • Gu QQ; a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , P. R. China.
  • Li DH; a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , P. R. China.
  • Zhu TJ; b Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Qingdao , P. R. China.
Nat Prod Res ; 33(3): 414-419, 2019 Feb.
Article em En | MEDLINE | ID: mdl-29600717
A new polyene compound (1) and a new diketopiperazine (2), as well as three known compounds (3-5), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1-5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC50 value of 12.7 µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Polienos / Dicetopiperazinas Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Polienos / Dicetopiperazinas Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2019 Tipo de documento: Article