TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer.

Gong, Ke; Guo, Gao; Gerber, David E; Gao, Boning; Peyton, Michael; Huang, Chun; Minna, John D; Hatanpaa, Kimmo J; Kernstine, Kemp; Cai, Ling; Xie, Yang; Zhu, Hong; Fattah, Farjana J; Zhang, Shanrong; Takahashi, Masaya; Mukherjee, Bipasha; Burma, Sandeep; Dowell, Jonathan; Dao, Kathryn; Papadimitrakopoulou, Vassiliki A; Olivas, Victor; Bivona, Trever G; Zhao, Dawen; Habib, Amyn A

Gong, Ke; Guo, Gao; Gerber, David E; Gao, Boning; Peyton, Michael; Huang, Chun; Minna, John D; Hatanpaa, Kimmo J; Kernstine, Kemp; Cai, Ling; Xie, Yang; Zhu, Hong; Fattah, Farjana J; Zhang, Shanrong; Takahashi, Masaya; Mukherjee, Bipasha; Burma, Sandeep; Dowell, Jonathan; Dao, Kathryn; Papadimitrakopoulou, Vassiliki A; Olivas, Victor; Bivona, Trever G; Zhao, Dawen; Habib, Amyn A.

Afiliação

Gong K; Department of Neurology and Neurotherapeutics.
Guo G; Department of Neurology and Neurotherapeutics.
Gerber DE; Internal Medicine, Division of Hematology-Oncology.
Gao B; Harold C. Simmons Comprehensive Cancer Center.
Peyton M; Department of Pharmacology.
Huang C; Hamon Center for Therapeutic Oncology Research.
Minna JD; Department of Pharmacology.
Hatanpaa KJ; Hamon Center for Therapeutic Oncology Research.
Kernstine K; Department of Pharmacology.
Cai L; Hamon Center for Therapeutic Oncology Research.
Xie Y; Internal Medicine, Division of Hematology-Oncology.
Zhu H; Department of Pharmacology.
Fattah FJ; Hamon Center for Therapeutic Oncology Research.
Zhang S; Department of Pathology.
Takahashi M; Department of Cardiovascular and Thoracic Surgery.
Mukherjee B; Quantitative Biomedical Research Center.
Burma S; Quantitative Biomedical Research Center.
Dowell J; Harold C. Simmons Comprehensive Cancer Center.
Dao K; Department of Clinical Sciences.
Papadimitrakopoulou VA; Harold C. Simmons Comprehensive Cancer Center.
Olivas V; Department of Radiology, and.
Bivona TG; Department of Radiology, and.
Zhao D; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Habib AA; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

J Clin Invest ; 128(6): 2500-2518, 2018 06 01.

Article em En | MEDLINE | ID: mdl-29613856

Assuntos

Resistencia a Medicamentos Antineoplásicos; Neoplasias Pulmonares/metabolismo; Proteínas de Neoplasias; Neoplasias Experimentais/metabolismo; Fator de Necrose Tumoral alfa; Células A549; Animais; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/terapia; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/genética; Receptores ErbB/metabolismo; Feminino; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Neoplasias Pulmonares/terapia; Camundongos; Camundongos Nus; MicroRNAs/genética; MicroRNAs/metabolismo; Proteínas de Neoplasias/antagonistas & inibidores; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo; Neoplasias Experimentais/genética; Neoplasias Experimentais/patologia; Neoplasias Experimentais/terapia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; RNA Neoplásico/genética; RNA Neoplásico/metabolismo; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Lung cancer; Protein kinases; Therapeutics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Resistencia a Medicamentos Antineoplásicos / Neoplasias Pulmonares / Proteínas de Neoplasias / Neoplasias Experimentais Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Clin Invest Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google