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Higher concentration of interleukin 6 - A possible link between major depressive disorder and childhood abuse.
Munjiza, Ana; Kostic, Milutin; Pesic, Danilo; Gajic, Milan; Markovic, Ivanka; Tosevski, Dusica Lecic.
Afiliação
  • Munjiza A; Institute of Mental Health, Belgrade, Serbia. Electronic address: ani_0902@yahoo.com.
  • Kostic M; Institute of Mental Health, Belgrade, Serbia; Department of Psychiatry, School of Medicine, University of Belgrade, Belgrade, Serbia.
  • Pesic D; Institute of Mental Health, Belgrade, Serbia.
  • Gajic M; Department of Statistics, School of Medicine, University of Belgrade, Belgrade, Serbia.
  • Markovic I; Institute for Biochemistry, School of Medicine, University of Belgrade, Belgrade, Serbia.
  • Tosevski DL; Institute of Mental Health, Belgrade, Serbia; Department of Psychiatry, School of Medicine, University of Belgrade, Belgrade, Serbia; Serbian Academy of Sciences and Arts, Belgrade, Serbia.
Psychiatry Res ; 264: 26-30, 2018 06.
Article em En | MEDLINE | ID: mdl-29626828
Little is known about the correlation between IL-6 and childhood abuse and neglect which may be risk factors for the development of affective disorders in adulthood. The aim of this study was to analyze differences in serum concentrations of IL-6 between patients with major depressive disorder and healthy controls, and to investigate possible correlations with adverse childhood experiences. Peripheral venous blood samples were obtained from 64 patients who fulfilled DSM-IV-R criteria for a current major depressive episode without psychotic symptoms (MDD) and 53 healthy controls, matched for age and gender. Participants were assessed by the Beck Depression Inventory (BDI), Childhood Trauma Questionnaire (CTQ), Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS). The concentration of IL-6 was significantly higher in patients with major depressive disorder compared to healthy controls. The total score of childhood trauma questionnaire highly statistically significantly correlated with IL-6 levels in patient group. Persons who were physically abused, physically neglected and emotionally abused had higher levels of IL-6. Interleukin 6 as a pro-inflammatory immune marker could be an important developmental mediator linking physical and emotional abuse in early life with the development of depressive disorder in adulthood.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Maus-Tratos Infantis / Interleucina-6 / Transtorno Depressivo Maior / Sobreviventes Adultos de Maus-Tratos Infantis Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Limite: Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Maus-Tratos Infantis / Interleucina-6 / Transtorno Depressivo Maior / Sobreviventes Adultos de Maus-Tratos Infantis Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Limite: Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Ano de publicação: 2018 Tipo de documento: Article