Biophysical characterization and molecular simulation of electrostatically driven self-association of a single-chain antibody.

O'Brien, Christopher J; Calero-Rubio, Cesar; Razinkov, Vladimir I; Robinson, Anne S; Roberts, Christopher J

O'Brien, Christopher J; Calero-Rubio, Cesar; Razinkov, Vladimir I; Robinson, Anne S; Roberts, Christopher J.

Afiliação

O'Brien CJ; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, 19716.
Calero-Rubio C; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, 19716.
Razinkov VI; Drug Product Development, Amgen Inc., Thousand Oaks, California, 91320.
Robinson AS; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, 19716.
Roberts CJ; Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Los Angeles, 70118.

Protein Sci ; 27(7): 1275-1285, 2018 07.

Article em En | MEDLINE | ID: mdl-29637646

Assuntos

Anticorpos de Cadeia Única/química; Difusão Dinâmica da Luz; Modelos Moleculares; Concentração Osmolar; Agregados Proteicos; Homologia de Sequência de Aminoácidos; Eletricidade Estática; Ultracentrifugação

Palavras-chave

coarse-grained modeling; molecular simulations; protein self-association; protein-protein interactions; single-chain variable fragments

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos de Cadeia Única Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Protein Sci Ano de publicação: 2018 Tipo de documento: Article

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