Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury.
J Neurotrauma
; 35(14): 1646-1658, 2018 07 15.
Article
em En
| MEDLINE
| ID: mdl-29648973
ABSTRACT
We previously reported that traumatic brain injuries (TBI) alter the cerebrovasculature near the injury site in rats, followed by revascularization over a 2-week period. Here, we tested our hypothesis that male and female adult mice have differential cerebrovascular responses following a moderate controlled cortical impact (CCI). Using in vivo magnetic resonance imaging (MRI), a new technique called vessel painting, and immunohistochemistry, we found no differences between males and females in lesion volume, neurodegeneration, blood-brain barrier (BBB) alteration, and microglia activation. However, females exhibited more astrocytic hypertrophy and heme-oxygenase-1 (HO-1) induction at 1 day post-injury (dpi), whereas males presented with increased endothelial activation and expression of ß-catenin, shown to be involved in angiogenesis. At 7 dpi, we observed an increase in the number of vessels and an enhancement in vessel complexity in the injured cortex of males compared with females. Cerebrovasculature recovers differently after CCI, suggesting biological sex should be considered when designing new therapeutic agents.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Caracteres Sexuais
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Lesões Encefálicas Traumáticas
Limite:
Animals
Idioma:
En
Revista:
J Neurotrauma
Ano de publicação:
2018
Tipo de documento:
Article