Serum Toll-like receptor 4: A novel and promising biomarker for identification of aortic aneurysmal diseases.
Clin Chim Acta
; 483: 69-75, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29649455
ABSTRACT
BACKGROUND:
Immune inflammation appears to play a role in aortic aneurysm (AA) pathology. Toll-like receptor 4 (TLR4) has been proved to involve in immune inflammatory diseases. However, the relationship between serum TLR4 and AA is still unclear.METHODS:
The study included 282 AA patients and 287 controls. The clinical test related information was collected in medical records. The levels of serum TLR4 were measured by enzyme-linked immunosorbent assay.RESULTS:
Serum TLR4 levels were significantly higher in case groups and could be influenced by age, smoking, hypertension, diabetes and hyperlipidemia. Serum TLR4 was positively correlated with circulating CRP, Hcy, D-dimer, Fg and Cys-c in AA patients, even after adjusting the possible influencing factors. The optimal cut-off value of TLR4 was 13.64â¯ng/ml for discriminating AA, and the screening accuracy was higher for those who were males (sensitivity of 63.5% and specificity of 68.6%), smokers (sensitivity of 63.5% and specificity of 82.7%) and hyperlipidemia (sensitivity of 59.1% and specificity of 81.2%). Multiple logistic analyses showed that serum TLR4 was significantly correlated with AA risk (ORâ¯=â¯1.119, 95% CIâ¯=â¯1.077-1.162, pâ¯<â¯0.001) and subjects with high TLR4 levels (>13.64â¯ng/ml) were more likely to have AAâ¯(ORâ¯=â¯4.225, 95% CIâ¯=â¯2.477-7.206, pâ¯<â¯0.001).CONCLUSIONS:
Serum TLR4 was closely related to AA and associated with some AA-related circulating markers. Serum TLR4 could be a novel and promising biomarker with important diagnostic and predictive value in the identification of aortic aneurysmal diseases.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aneurisma Aórtico
/
Receptor 4 Toll-Like
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Chim Acta
Ano de publicação:
2018
Tipo de documento:
Article