Dissecting the signaling features of the multi-protein complex GPCR/ß-arrestin/ERK1/2.
Eur J Cell Biol
; 97(5): 349-358, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29665971
ABSTRACT
G protein-coupled receptors (GPCRs) have emerged as key biological entities that regulate a plethora of physiological processes and participate in the onset and development of many diseases. Moreover, these receptors are important targets of almost 25% of the current therapeutic drugs in the market. Upon agonist binding, GPCRs activate a great number of signaling pathways, resulting in important cellular events like gene transcription, survival, proliferation and differentiation. In order to activate such events, GPCRs interact with a variety of scaffold and molecular entities, particularly with G proteins, but also with ß-arrestins and the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway, forming unique signaling modules. The aim of this review is to analyze the signaling features of the multi-protein complex GPCR-ß-arrestin-ERK1/2, a unique signaling module that has received considerable attention from different research groups due to its molecular and physiological roles in diverse cellular contexts.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Acoplados a Proteínas G
/
Proteína Quinase 3 Ativada por Mitógeno
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Eur J Cell Biol
Ano de publicação:
2018
Tipo de documento:
Article