Positioning Europe for the EPITRANSCRIPTOMICS challenge.
RNA Biol
; 15(6): 829-831, 2018.
Article
em En
| MEDLINE
| ID: mdl-29671387
ABSTRACT
The genetic alphabet consists of the four letters C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA de Neoplasias
/
RNA Neoplásico
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Regulação Neoplásica da Expressão Gênica
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Perfilação da Expressão Gênica
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Epigênese Genética
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Epigenômica
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Transcriptoma
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Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
RNA Biol
Ano de publicação:
2018
Tipo de documento:
Article