Donated chemical probes for open science.
Elife
; 72018 04 20.
Article
em En
| MEDLINE
| ID: mdl-29676732
ABSTRACT
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Farmacologia
/
Sondas Moleculares
/
Proteínas
/
Tecnologia Farmacêutica
Idioma:
En
Revista:
Elife
Ano de publicação:
2018
Tipo de documento:
Article