A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration.

Shin, Younghwa; Moiseyev, Gennadiy; Petrukhin, Konstantin; Cioffi, Christopher L; Muthuraman, Parthasarathy; Takahashi, Yusuke; Ma, Jian-Xing

Shin, Younghwa; Moiseyev, Gennadiy; Petrukhin, Konstantin; Cioffi, Christopher L; Muthuraman, Parthasarathy; Takahashi, Yusuke; Ma, Jian-Xing.

Afiliação

Shin Y; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
Moiseyev G; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States. Electronic address: gennadiy-moiseyev@ouhsc.edu.
Petrukhin K; Department of Ophthalmology, Columbia University, New York, NY 10032, United States.
Cioffi CL; Departments of Basic & Clinical Sciences and Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, United States.
Muthuraman P; Departments of Basic & Clinical Sciences and Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, United States.
Takahashi Y; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United states.
Ma JX; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.

Biochim Biophys Acta Mol Basis Dis ; 1864(7): 2420-2429, 2018 Jul.

Article em En | MEDLINE | ID: mdl-29684583

Assuntos

Inibidores Enzimáticos/farmacologia; Degeneração Retiniana; Visão Ocular; cis-trans-Isomerases; Animais; Diterpenos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Mutantes; Degeneração Retiniana/tratamento farmacológico; Degeneração Retiniana/enzimologia; Degeneração Retiniana/genética; Degeneração Retiniana/patologia; Ésteres de Retinil; Visão Ocular/efeitos dos fármacos; Visão Ocular/genética; Vitamina A/análogos & derivados; Vitamina A/metabolismo; cis-trans-Isomerases/antagonistas & inibidores; cis-trans-Isomerases/genética; cis-trans-Isomerases/metabolismo

Palavras-chave

Age-related macular degeneration; Enzyme inhibitor; RPE65; Retinal degeneration; Stargardt's disease; Visual cycle

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Visão Ocular / Cis-trans-Isomerases / Inibidores Enzimáticos Limite: Animals Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Ano de publicação: 2018 Tipo de documento: Article

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