Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates.
Chemistry
; 24(47): 12250-12253, 2018 Aug 22.
Article
em En
| MEDLINE
| ID: mdl-29729206
ABSTRACT
Targeted delivery of potent cytotoxic drugs to cancer cells minimizes systemic toxicity and several side effects. NHC*-Au-Cl has already been proven to be a potent anticancer agent. In this study, we explore a strategy based on chemoselective cysteine conjugation of NHC*-Au-Cl to albumin and trastuzumab (Thiomab LC-V205C) to potentiate drug-ligand ratio, pharmacokinetics, as well as drug efficacy and safety. This strategy is a step forward towards the use of gold-based anticancer agents as targeted therapies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
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Albumina Sérica
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Imidazolinas
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Trastuzumab
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Ouro
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Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Chemistry
Ano de publicação:
2018
Tipo de documento:
Article