[Relationship between the FSHR Thr307Ala-Asn680Ser gene polymorphism and male infertility: A meta-analysis].
Zhonghua Nan Ke Xue
; 23(12): 1121-1126, 2017 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-29738186
ABSTRACT
OBJECTIVE:
To assess the association of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility.METHODS:
We searched Pubmed, EMBASE, Web of Science, CNKI, and WANFANG databases for literature on the correlation of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility published from 2005 to the present time. According to the inclusion criteria, we included 12 epidemiological case-control studies and subjected them to a comprehensive analysis with the Stata11.0 software.RESULTS:
A total of 2 893 male infertility patients and 3 312 controls were involved in the 12 studies. The Thr307Ala (rs6165) gene polymorphism was shown to be a risk factor for male infertility among the three comparison models (homozygous comparison model, hybrid comparison model and dominant comparison model), with the pooled odds ratios (OR) of 1.26 (95% CI 1.03ï¼1.54, P = 0.023), 1.18 (95% CI 1.03ï¼1.36, P = 0.018), and 1.20 (95% CI 1.05ï¼1.37, P = 0.006), respectively. And the Asn680Ser(rs6166) polymorphism was a risk factor for male infertility in the homozygous comparison and recessive comparison models, with the pooled ORs of 1.24, (95% CI 1.05ï¼1.45, P = 0.009) and 1.20 (95% CI 1.04ï¼1.39, P = 0.013), respectively. Layered meta-analysis showed that in the homozygous comparison model, the Thr307Ala-Asn680Ser polymorphism is a risk factor for male infertility in the white population, with the OR of 1.37 (95% CI 1.03ï¼1.82, P = 0.003) and 1.21 (95% CI 1.00ï¼1.47, P = 0.048), respectively.CONCLUSIONS:
In the homozygous model (GG vs AA), the FSHRThr307Ala-Asn680Ser gene polymorphism might be a protective factor against male infertility.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Hormônio Foliculoestimulante Humano
/
Infertilidade Masculina
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua Nan Ke Xue
Ano de publicação:
2017
Tipo de documento:
Article