Improved detection sensitivity of γ-aminobutyric acid based on graphene oxide interface on an optical microfiber.
Phys Chem Chem Phys
; 20(20): 14117-14123, 2018 May 23.
Article
em En
| MEDLINE
| ID: mdl-29748670
ABSTRACT
Interfacing bio-recognition elements to optical materials is a longstanding challenge to manufacture sensitive biosensors and inexpensive diagnostic devices. In this work, a graphene oxide (GO) interface has been constructed between silica microfiber and bio-recognition elements to develop an improved γ-aminobutyric acid (GABA) sensing approach. The GO interface, which was located at the site with the strongest evanescent field on the microfiber surface, improved the detection sensitivity by providing a larger platform for more bio-recognition element immobilization, and amplifying surface refractive index change caused by combination between bio-recognition elements and target molecules. Owing to the interface improvement, the microfiber has a three times improved sensitivity of 1.03 nm/log M for GABA detection, and hence a lowest limit of detection of 2.91 × 10-18 M, which is 7 orders of magnitude higher than that without the GO interface. Moreover, the micrometer-sized footprint and non-radioactive nature enable easy implantation in human brains for in vivo applications.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Phys Chem Chem Phys
Ano de publicação:
2018
Tipo de documento:
Article